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1,2,4,5-四嗪-胺反应

1,2,4,5-四嗪-胺反应

1,2,4,5-四嗪 (S-Tetrazine) 的羧酸或者琥珀酰亚胺酯衍生物，可与带有氨基的小分子发生反应，形成稳定的酰胺键连接。

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客户近期使用本公司产品发表的高影响因子论文（IF>10）

Amplifying antigen-induced cellular responses with proximity labelling
Intelligent Nano-Cage for Precision Delivery of CRISPR-Cas9 and ACC Inhibitors to Enhance Antitumor Cascade Therapy Through Lipid Metabolism Disruption
Multimodal targeting chimeras enable integrated immunotherapy leveraging tumor-immune microenvironment
A Versatile One-Step Enzymatic Strategy for Efficient Imaging and Mapping of Tumor-Associated Tn Antigen
Surface-anchored tumor microenvironment-responsive protein nanogel-platelet system for cytosolic delivery of therapeutic protein in the post-surgical cancer treatment
Genetically Incorporated Non-Canonical Amino Acids
Boosting Dye-Sensitized Luminescence by Enhanced Short-Range Triplet Energy Transfer
Global profiling of functional histidines in live cells using small-molecule photosensitizer and chemical probe relay labelling
Spatiotemporal-resolved protein networks profiling with photoactivation dependent proximity labeling
A proof-of-concept study on bioorthogonal-based pretargeting and signal amplify radiotheranostic strategy
Bioengineered Platelets Combining Chemotherapy and Immunotherapy for Postsurgical Melanoma Treatment: Internal Core-Loaded Doxorubicin and External Surface-Anchored Anti-PDL1 Antibody Backpacks
Scalable Synthesis of Highly Stable Cyclopropene Building Blocks: Application for Bioorthogonal Ligation with Tetrazines
Noncanonical amino acids as doubly bio-orthogonal handles for one-pot preparation of protein multiconjugates
Reversible control of tetrazine bioorthogonal reactivity by naphthotube-mediated host-guest recognition
An Optimized Isotopic Photocleavable Tagging Strategy for SiteSpecific and Quantitative Profiling of Protein O‑GlcNAcylation in Colorectal Cancer Metastasis

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